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Sermorelin and Ipamorelin both stimulate growth hormone release but through different pathways. Sermorelin is a truncated GHRH (amino acids 1-29) that works through GHRH receptors, while Ipamorelin is a GHRP that acts on ghrelin receptors. Sermorelin has a longer clinical history, while Ipamorelin is known for its selectivity and minimal side effects.
| Category | Sermorelin | Ipamorelin |
|---|---|---|
| Class | GHRH analog (1-29) | GHRP (Ghrelin mimetic) |
| Receptor Target | GHRH receptor | Ghrelin receptor (GHS-R) |
| Clinical History | Long (FDA approved historically) | Research compound |
| Side Effect Profile | Mild, well-characterized | Very mild, highly selective |
| Price Range | From $44.99 | From $39.99 |
| Purity | ≥99% HPLC | ≥99% HPLC |
Has been FDA approved and used clinically
More selective with minimal cortisol/prolactin effects
Works through natural GHRH pathway
Can be combined with GHRH analogs for enhanced effects
Both have good safety profiles in research. Sermorelin has more clinical history, while Ipamorelin is known for high selectivity.
Yes, they target different receptors and may be combined for potentially synergistic GH release, similar to CJC-1295 + Ipamorelin combinations.
Sermorelin mimics natural GHRH more closely, while Ipamorelin works through a separate ghrelin pathway.
GHRH analog for growth hormone research applications.
Selective growth hormone secretagogue for GH research.
Our AI analyzes your specific research goals to recommend the best peptide for you.
Get AI RecommendationChoosing between Sermorelin and Ipamorelin is a common question in growth hormone research. This comprehensive comparison breaks down the key differences to help you make an informed decision for your research needs.
The primary distinction between these peptides lies in their mechanisms:
The right choice depends on your specific research goals:
If you're still unsure which peptide is right for your research, Poly Biotech offers industry-first AI tools to help:
Regardless of which peptide you choose, all Poly Biotech products meet our strict quality standards: ≥99% HPLC verified purity, Certificate of Analysis included, proper storage and handling, and fast shipping to all 50 US states.
Both Sermorelin and Ipamorelin available with ≥99% purity.