GHK-Cu Research Guide
Copper peptide research for skin and tissue studies
Overview
GHK-Cu (Glycyl-L-histidyl-L-lysine copper) is a naturally occurring copper complex tripeptide found in human plasma, saliva, and urine. First identified in 1973, it has been extensively studied for its role in wound healing, tissue remodeling, and gene expression modulation.
Molecular Formula
C14H24N6O4Cu
Molecular Weight
403.92 g/mol
Sequence
Gly-His-Lys:Cu
CAS Number
49557-75-7
Mechanism of Action
GHK-Cu exerts its effects through multiple pathways:
- Copper delivery: Facilitates copper uptake into cells, essential for multiple enzyme functions
- Gene expression: Modulates expression of over 4,000 genes involved in tissue remodeling
- Antioxidant activity: Upregulates superoxide dismutase and other antioxidant enzymes
- ECM remodeling: Promotes collagen and glycosaminoglycan synthesis
Research Applications
Wound Healing Studies
Research on keratinocyte migration, fibroblast activation, and angiogenesis in wound models
Skin Biology
Studies on collagen synthesis, elastin production, and dermal thickness in aging models
Hair Follicle Research
Investigation of hair follicle cell proliferation and follicle size in dermal papilla models
Anti-inflammatory Studies
Research on inflammatory cytokine modulation and tissue protection mechanisms
Neuroregeneration
Studies on nerve growth factor secretion and neuronal cell protection
Storage Guidelines
Lyophilized Powder
Store at -20°C protected from light. Stable for 24+ months when properly stored.
Reconstituted Solution
Store at 2-8°C. Use within 2-3 weeks. Protect from light and oxidation.
Reconstitution Notes
Reconstitute in sterile water or PBS. The copper complex gives a characteristic blue color.
Stability Note
GHK-Cu is sensitive to oxidation. Use nitrogen overlay or argon when storing reconstituted solutions.
Research Use Only
GHK-Cu is sold strictly for laboratory research purposes. It is not approved for human or veterinary use. This information is provided for educational purposes only and does not constitute medical advice. Researchers must comply with all applicable regulations.