Not sure which is right for you? Our AI can analyze your specific goals
This comparison examines the evolution from dual to triple agonism in metabolic peptide research. Tirzepatide activates GIP and GLP-1 receptors, while Retatrutide adds glucagon receptor activation for a triple mechanism. The glucagon component may provide additional metabolic benefits through increased energy expenditure, making Retatrutide a cutting-edge research compound.
| Category | Tirzepatide | Retatrutide |
|---|---|---|
| Mechanism | Dual agonist (GIP + GLP-1) | Triple agonist (GIP + GLP-1 + Glucagon) |
| Receptor Targets | 2 receptors | 3 receptors |
| Development Stage | FDA approved | Phase 3 trials |
| Energy Expenditure | Indirect effects | Direct glucagon-mediated effects |
| Price Range | From $189.99 | From $199.99 |
| Purity | ≥99% HPLC | ≥99% HPLC |
More published data and FDA approval
Triple agonism represents cutting-edge approach
Early data suggests enhanced metabolic effects
Already FDA approved for clinical use
Retatrutide adds glucagon receptor activation, which may increase energy expenditure and provide additional metabolic benefits beyond GIP/GLP-1 effects.
Early research suggests potentially greater effects, but more clinical data is needed. Tirzepatide has more established research and regulatory approval.
Retatrutide is currently in Phase 3 clinical trials, with more comprehensive data expected in the coming years.
Dual GIP/GLP-1 receptor agonist for advanced metabolic research.
Triple agonist (GIP/GLP-1/Glucagon) for advanced metabolic research.
Our AI analyzes your specific research goals to recommend the best peptide for you.
Get AI RecommendationChoosing between Tirzepatide and Retatrutide is a common question in weight management research. This comprehensive comparison breaks down the key differences to help you make an informed decision for your research needs.
The primary distinction between these peptides lies in their mechanisms:
The right choice depends on your specific research goals:
If you're still unsure which peptide is right for your research, Poly Biotech offers industry-first AI tools to help:
Regardless of which peptide you choose, all Poly Biotech products meet our strict quality standards: ≥99% HPLC verified purity, Certificate of Analysis included, proper storage and handling, and fast shipping to all 50 US states.
Both Tirzepatide and Retatrutide available with ≥99% purity.